Jmol.jmolLink(jmolApplet0,"select all;spacefill off; wireframe .1;","Sticks") 1 ( Yoshida et al., 2013 ). No votes so far! These linkages have been employed in various drug delivery vehicles, such as linear polymers, star shaped polymers, dendrimers, micelles, liposomes and inorganic nanoparticles, for pH-responsive drug delivery. redistribute this material, requesters must process their own requests via the RightsLink permission The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at with additional details about the score and the social media presence for the given article. Hydrazones generally form a mixture of geometric isomers. Hydrazones can also be synthesized by the Japp–Klingemann reaction via β-keto-acids or β-keto-esters and aryl diazonium salts. But opting out of some of these cookies may have an effect on your browsing experience. OH-initiated transformation and hydrolysis of aspirin in AOPs system: DFT and experimental studies. not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information Hydrazone chemistry is widely utilized in biomedical field as a means of bioconjugation protocol, especially in drug delivery field due to pH labile nature of this linkage. Information about how to use the RightsLink permission system can be found at Jmol.jmolLink(jmolApplet0,"select all;spacefill 20%; wireframe .15;","Ball & Stick") In the light of kinetic studies, the generally accepted mechanism for the hydrolysis of hydrazones involves two main steps, namely nucleophilic addition of …,,,,,, This category only includes cookies that ensures basic functionalities and security features of the website. Your Mendeley pairing has expired. Note the similarity to the formation of an oxime reaction. We use cookies to help provide and enhance our service and tailor content and ads. These cookies do not store any personal information. We gratefully acknowledge support from the UK Physical Sciences Centre, HEA (National Teaching Fellowship), JISC, Faculty of Science TQEF and EPSRC. European Journal of Pharmaceutical Sciences, ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Hydrazone linkages in pH responsive drug delivery systems. Soc., 1974, 96, 7998–8009. Hydrazone Hydrazones are compounds containing the group >CNN, and they are typically generated by the elimination of a water molecule between a hydrazine and a carbonyl compound (aldehyde or ketone).From: Pyrolysis of


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